((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester - Names and Identifiers
Name | (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine
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Synonyms | N-Boc-1R,2R-Cyclohexanediamine 1R)-trans-N-Boc-1,2-diaminocyclohexane (1R)-trans-N-Boc-1,2-diaminocyclohexane (1R,2R)-trans-N-Boc-1,2-cyclohexanediamine (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine Trans (1R,2R)-1N-Boc-cyclohexane-1,2-diamine (1R,2R)-N-tert.-Butoxycarbonylcyclohexane-1,2-diamine (1R,2R)-(-)-N-(t-Butoxycarbonyl)-1,2-cyclohexanediamine ((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester Carbamic acid, N-[(1R,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester
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CAS | 146504-07-6
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InChIKey | AKVIZYGPJIWKOS-RKDXNWHRSA-N |
((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester - Physico-chemical Properties
Molecular Formula | C11H22N2O2
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Molar Mass | 214.3 |
Density | 1.02±0.1 g/cm3(Predicted) |
Melting Point | 114-115℃ |
Boling Point | 322.1±31.0 °C(Predicted) |
BRN | 7023564 |
pKa | 12.26±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester - Risk and Safety
Hazard Symbols | C - Corrosive
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Risk Codes | 34 - Causes burns
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
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UN IDs | UN 3259 8/PG 3 |
WGK Germany | 3 |
HS Code | 29242990 |
Hazard Class | 8 |
Packing Group | Ⅲ |
((1R,2R)-2-Aminocyclohexyl)-carbamic acid tert-butyl ester - Introduction
(1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine is a chiral organic compound. The following is an introduction to the properties, applications, preparation methods and safety information of the compound:
Nature:
-Appearance: Colorless or light yellow oily liquid.
-Molecular formula: C10H20N2O
-Molecular weight: 188.28g/mol
-Melting point:-35 ° C
-Boiling point: 140-142 ° C
-Refractive index: n20/D 1.488
Use:
(1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine is an important Chiral synthesis intermediate, which has a wide range of applications in organic synthesis. It is commonly used in the fields of catalysts, pharmaceuticals and materials science.
Method:
The preparation method of (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine can be carried out by the following steps:
1. First, tert-butyl alcohol (t-butanol) is reacted with chloroformic acid (chloroformic acid) to produce tert-butoxycarbonyl chloroformate (t-butoxycarbonyl chloroformate).
2. Then, the tert-butoxycarbonyl chloroformate is reacted with pyridine in the presence of 1,2-cyclohexanediamine to give the target product (1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine.
Safety Information:
(1R,2R)-trans-N-Boc-1,2-Cyclohexanediamine Note the following safety information:
-This compound may be irritating to the eyes, skin and respiratory tract, so direct contact should be avoided when using it.
-Wear appropriate personal protective equipment, such as lab gloves, goggles or face shield, when operating.
-It should be used in a well-ventilated place and avoid prolonged exposure to the air.
-During storage and handling, attention should be paid to isolation from oxidants, strong acids and strong bases to avoid accidental chemical reactions.
-If ingested or inhaled, seek medical attention immediately.
Last Update:2024-04-09 21:01:54